KHSRP HAS ONCOGENIC FUNCTIONS AND REGULATES THE EXPRESSION AND ALTERNATIVE SPLICING OF DNA REPAIR GENES IN BREAST CANCER MDA-MB-231 CELLS

KHSRP has oncogenic functions and regulates the expression and alternative splicing of DNA repair genes in breast cancer MDA-MB-231 cells

Abstract Breast cancer has become the most common type of cancers worldwide.Its high prevalence and malignant features are associated with various environmental factors and molecules.The KH-type splicing regulatory protein (KHSRP) participates in the development of breast cancer, while the underlying mechanisms are largely unknown.In this study, we

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Is Therapeutic Drug Monitoring Relevant for Antidepressant Drug Therapy? Implications From a Systematic Review and Meta-Analysis With Focus on Moderating Factors

Inter-individual differences in antidepressant drug concentrations attained in blood may limit the efficacy of pharmacological treatment of depressive disorders.Therapeutic drug monitoring (TDM) enables to determine drug concentrations in blood and adjust antidepressant dosage accordingly.However, research on the underlying assumption of TDM, assoc

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Noninvasive fetal genotyping of single nucleotide variants and linkage analysis for prenatal diagnosis of monogenic disorders

Abstract Background High-cost, time-consuming and complex processes of several current approaches limit the use of noninvasive prenatal diagnosis (NIPD) for monogenic disorders in clinical application.Thus, a more cost-effective and easily implementable approach is DIESEL PROTEIN CHOCOLATE required.Methods We established a low-cost and convenient t

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